Job Description
The department of Pharmacokinetics, Dynamics, Metabolism and Bioanalytics (PDMB) is seeking a curious and collaborative scientist for our growing Translational PK/PD organization. The Translational PK/PD Senior Specialist is responsible for driving application of our modeling and simulation capabilities to enable earlier and more confident decision making around PK/PD, modality selection and dose prediction across all therapeutic areas for small molecule, peptide and protein therapeutics. Senior Specialists are skilled modelers that achieve results by interacting with multi-disciplinary discovery teams and partners from other functions within our company.
The Translational PK/PD Senior Specialist role will help to drive impact in the drug discovery and translational space by:
- Incorporating in vitro and in vivo data into systems models (PBPK and PK/PD) of drug disposition and pharmacology in support of translational and reverse translational efforts across multiple modalities and therapeutic areas
- Understanding the impact of drug disposition on novel disease biology and pharmacological response (PK/PD) to inform human PK and dose projections
- Closely collaborating with project teams and across the PDMB organization to develop modeling and simulation strategies to identify and optimize drug candidates
In addition to the responsibilities described above, Senior Specialists demonstrate strong communication skills collaborating across PDMB and with other functional areas to create a quantitative model-informed approach to impact program strategies and decision making on drug discovery teams through the application of translational PK/PD, mechanistic and PBPK models.
Required:
- PhD or equivalent degree or MS/PharmD with at least 3 years of drug discovery or development experience
- Experience in performing hands-on translational PK/PD modeling using standard modeling software (e.g., Phoenix, Berkeley Madonna, Monolix, Matlab, R)
- Expert skills in experimental design, mathematical problem solving, critical data analysis/interpretation, and statistics
Preferred:
- Proficiency in written and verbal communication and problem scoping and planning.
- Expertise in biologics/large molecule/protein therapeutics modeling
- Expertise in PBPK modeling
NOTICE FOR INTERNAL APPLICANTS
In accordance with Managers' Policy - Job Posting and Employee Placement, all employees subject to this policy are required to have a minimum of twelve (12) months of service in current position prior to applying for open positions.
If you have been offered a separation benefits package, but have not yet reached your separation date and are offered a position within the salary and geographical parameters as set forth in the Summary Plan Description (SPD) of your separationpackage, then you are no longer eligible for your separation benefits package. To discuss in more detail, please contact your HRBP or Talent Acquisition Advisor.
Employees working in roles that the Company determines require routine collaboration with external stakeholders, such as customer-facing commercial, or research-based roles, will be expected to comply not only with Company policy but also with policies established by such external stakeholders (for example, a requirement to be vaccinated against COVID-19 in order to access a facility or meet with stakeholders). Please understand that, as permitted by applicable law, if you have not been vaccinated against COVID-19 and an essential function of your job is to call on external stakeholders who require vaccination to enter their premises or engage in face-to-face meetings, then your employment may pose an undue burden to business operations, in which case you may not be offered employment, or your employment could be terminated. Please also note that, where permitted by applicable law, the Company reserves the right to require COVID-19 vaccinations for positions, such as in Global Employee Health, where the Company determines in its discretion that the nature of the role presents an increased risk of disease transmission.
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U.S. Hybrid Work Model
Effective September 5, 2023, employees in office-based positions in the U.S. will be working a Hybrid work consisting of three total days on-site per week, generally Tuesday, Wednesday and either Monday or Thursday, although the specific days may vary by site or organization, with Friday designated as a remote-working day, unless business critical tasks require an on-site presence. This Hybrid work model does not apply to, and daily in-person attendance is required for, field-based positions; facility-based, manufacturing-based, or research-based positions where the work to be performed is located at a Company site; positions covered by a collective-bargaining agreement (unless the agreement provides for hybrid work); or any other position for which the Company has determined the job requirements cannot be reasonably met working remotely. Please note, this Hybrid work model guidance also does not apply to roles that have been designated as "remote".
The Company is required to provide a reasonable estimate of the salary range for this job in certain states and cities within the United States. Final determinations with respect to salary will take into account a number of factors, which may include, but not be limited to the primary work location and the chosen candidate's relevant skills, experience, and education.
Expected US salary range:
$122,800.00 - $193,300.00Available benefits include bonus eligibility, long term incentive if applicable, health care and other insurance benefits (for employee and family), retirement benefits, paid holidays, vacation, and sick days. A summary of benefits is listed here.
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Merck & Co., Inc., Rahway, NJ, USA, also known as Merck Sharp & Dohme LLC, Rahway, NJ, USA, does not accept unsolicited assistance from search firms for employment opportunities. All CVs / resumes submitted by search firms to any employee at our company without a valid written search agreement in place for this position will be deemed the sole property of our company. No fee will be paid in the event a candidate is hired by our company as a result of an agency referral where no pre-existing agreement is in place. Where agency agreements are in place, introductions are position specific. Please, no phone calls or emails.
Employee Status:
RegularRelocation:
Domestic/InternationalVISA Sponsorship:
YesTravel Requirements:
10%Flexible Work Arrangements:
HybridShift:
Not IndicatedValid Driving License:
NoHazardous Material(s):
N/ARequired Skills:
Business Intelligence (BI), Database Design, Data Engineering, Data Modeling, Data Science, Data Visualization, Machine Learning, Software Development, Stakeholder Relationship Management, Waterfall Project ManagementPreferred Skills:
Job Posting End Date:
10/7/2024*A job posting is effective until 11:59:59PM on the day BEFOREthe listed job posting end date. Please ensure you apply to a job posting no later than the day BEFORE the job posting end date.
Job Posting End Date:10/07/2024
A job posting is effective until 11:59:59PM on the day BEFORE the listed job posting end date. Please ensure you apply to a job posting no later than the day BEFORE the job posting end date.
Requisition ID:R309123